Nowogrodzki, Peter, author.

Mus musculus, GRCm38 primary reference assembly.

[Place of publication not identified] : Gauss PDF, 2014.

1 online resource.

Gauss PDF ; 108

"MISC NOTES >> The Mus musculus (house mouse) genome is comprised of 21 chromosomes. PDFs derived from the publicly available primary assembly for Mus musculus, GRCm38, released by the Genome Reference Consortium in January, 2012, and subsequently used by UCSC to create the mm10 database available on ensemble.org. The GRCm38 primary assembly is made up of 3,480,955,279 nucleotide base pairs, which collectively code some 23,148 genes, on nineteen chromosomes (pp. 1 - 709,409 pp.) as well as the sex chromosomes X and Y (terminal 75,257 pps.). The 13th chromosome alone is comprised of over 120 million nucleotide base pairs that code 1,572 genes. Many notable proteins are translated from information contained on this chromosome: msh homeobox 2; dopamine receptor D1A; MAD homolog 5. The ryanodine receptor 2, or RYR2, functions to supply calcium to cardiac muscle. Lysosomal trafficking regulator is a transport protein that, when mutant, results in Chédiak-Higashi syndrome, a cellular decrease in phagocytosis (the process by which a cell engulfs and isolates solid particles). The angiotensin II receptor, type 1a is a G-protein coupled receptor with vasopressor effects, namely within the cardiovascular system. A protein called endothelin 1 releases a peptide vasoconstrictor; in humans the EDN1 gene ortholog is located on chromosome 6. Spleen tyrosine kinase, aka Syk, is a member of the enzyme family of tyrosine kinases. Mice that lack Syk die during embryonic development of severe defects in the lymphatic system."-- provided by distributor.

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